Title |
No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial
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Published in |
Journal of Negative Results in BioMedicine, August 2012
|
DOI | 10.1186/1477-5751-11-13 |
Pubmed ID | |
Authors |
Philip Wilkens, Kjersti Storheim, Inger Scheel, Linda Berg, Ansgar Espeland |
Abstract |
The underlying pathology and natural course of Modic changes (MC) in the vertebral body marrow and high intensity zones (HIZs) in the annulus fibrosus is not completely clarified. These findings on magnetic resonance imaging (MRI) have initiated different treatments with little or unclear effect. In a randomized trial (n=250), glucosamine sulfate (GS) had no effect on low back pain related disability. GS could still have an effect on MC and HIZ. In this sub-study, 45 patients from the trial who had MC and/or HIZ at pre-treatment underwent follow-up MRI. The aim was to examine the course of MC and HIZ and to compare this course between groups treated with 6-month intake of oral GS versus placebo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 6 | 67% |
Netherlands | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 78% |
Scientists | 2 | 22% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 19% |
Researcher | 7 | 17% |
Student > Master | 4 | 10% |
Other | 3 | 7% |
Student > Bachelor | 3 | 7% |
Other | 7 | 17% |
Unknown | 10 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 29% |
Nursing and Health Professions | 6 | 14% |
Agricultural and Biological Sciences | 4 | 10% |
Neuroscience | 3 | 7% |
Social Sciences | 3 | 7% |
Other | 1 | 2% |
Unknown | 13 | 31% |