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X Demographics
Mendeley readers
Attention Score in Context
| Title |
AMD and the alternative complement pathway: genetics and functional implications
|
|---|---|
| Published in |
Human Genomics, June 2016
|
| DOI | 10.1186/s40246-016-0079-x |
| Pubmed ID | |
| Authors |
Perciliz L. Tan, Catherine Bowes Rickman, Nicholas Katsanis |
| Abstract |
Age-related macular degeneration (AMD) is an ocular neurodegenerative disorder and is the leading cause of legal blindness in Western societies, with a prevalence of up to 8 % over the age of 60, which continues to increase with age. AMD is characterized by the progressive breakdown of the macula (the central region of the retina), resulting in the loss of central vision including visual acuity. While its molecular etiology remains unclear, advances in genetics and genomics have illuminated the genetic architecture of the disease and have generated attractive pathomechanistic hypotheses. Here, we review the genetic architecture of AMD, considering the contribution of both common and rare alleles to susceptibility, and we explore the possible mechanistic links between photoreceptor degeneration and the alternative complement pathway, a cascade that has emerged as the most potent genetic driver of this disorder. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| Saudi Arabia | 1 | 14% |
| United Kingdom | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Egypt | 1 | <1% |
| Unknown | 121 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 14% |
| Researcher | 17 | 14% |
| Student > Bachelor | 14 | 11% |
| Other | 14 | 11% |
| Student > Doctoral Student | 11 | 9% |
| Other | 20 | 16% |
| Unknown | 29 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 25% |
| Biochemistry, Genetics and Molecular Biology | 19 | 16% |
| Neuroscience | 11 | 9% |
| Agricultural and Biological Sciences | 11 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Other | 11 | 9% |
| Unknown | 33 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2016.
All research outputs
#2,811,190
of 25,373,627 outputs
Outputs from Human Genomics
#75
of 564 outputs
Outputs of similar age
#49,212
of 369,274 outputs
Outputs of similar age from Human Genomics
#1
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 564 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.