Title |
Pseudogenization of the MCP-2/CCL8 chemokine gene in European rabbit (genus Oryctolagus), but not in species of Cottontail rabbit (Sylvilagus) and Hare (Lepus)
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Published in |
BMC Genomic Data, August 2012
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DOI | 10.1186/1471-2156-13-72 |
Pubmed ID | |
Authors |
Wessel van der Loo, Sandra Afonso, Ana Lemos de Matos, Joana Abrantes, Pedro J Esteves |
Abstract |
Recent studies in human have highlighted the importance of the monocyte chemotactic proteins (MCP) in leukocyte trafficking and their effects in inflammatory processes, tumor progression, and HIV-1 infection. In European rabbit (Oryctolagus cuniculus) one of the prime MCP targets, the chemokine receptor CCR5 underwent a unique structural alteration. Until now, no homologue of MCP-2/CCL8a, MCP-3/CCL7 or MCP-4/CCL13 genes have been reported for this species. This is interesting, because at least the first two genes are expressed in most, if not all, mammals studied, and appear to be implicated in a variety of important chemokine ligand-receptor interactions. By assessing the Rabbit Whole Genome Sequence (WGS) data we have searched for orthologs of the mammalian genes of the MCP-Eotaxin cluster. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Norway | 1 | 7% |
Unknown | 13 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 29% |
Student > Doctoral Student | 2 | 14% |
Student > Master | 2 | 14% |
Student > Ph. D. Student | 1 | 7% |
Other | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 43% |
Medicine and Dentistry | 4 | 29% |
Environmental Science | 1 | 7% |
Unknown | 3 | 21% |