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c-KIT receptor expression is strictly associated with the biological behaviour of thyroid nodules

Overview of attention for article published in Journal of Translational Medicine, January 2012
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Title
c-KIT receptor expression is strictly associated with the biological behaviour of thyroid nodules
Published in
Journal of Translational Medicine, January 2012
DOI 10.1186/1479-5876-10-7
Pubmed ID
Authors

Sara Tomei, Chiara Mazzanti, Ivo Marchetti, Leonardo Rossi, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio, Generoso Bevilacqua

Abstract

A large amount of information has been collected on the molecular tumorigenesis of thyroid cancer. A low expression of c-KIT gene has been reported during the transformation of normal thyroid epithelium to papillary carcinoma suggesting a possible role of the gene in the differentiation of thyroid tissue rather than in the proliferation. The initial presentation of thyroid carcinoma is through a nodule and the best way nowadays to evaluate it is by fine-needle aspiration (FNA). However many thyroid FNAs are not definitively benign or malignant, yielding an indeterminate or suspicious diagnosis which ranges from 10 to 25% of FNAs. BRAF mutational analysis is commonly used to assess the malignancy of thyroid nodules but unfortunately it still leaves indeterminate diagnoses. The development of molecular initial diagnostic tests for evaluating a thyroid nodule is needed in order to define optimal surgical approach for patients with uncertain diagnosis pre- and intra-operatively.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 41%
Student > Bachelor 2 12%
Student > Doctoral Student 1 6%
Lecturer > Senior Lecturer 1 6%
Student > Ph. D. Student 1 6%
Other 3 18%
Unknown 2 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 29%
Medicine and Dentistry 5 29%
Agricultural and Biological Sciences 4 24%
Veterinary Science and Veterinary Medicine 1 6%
Unknown 2 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2012.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from Journal of Translational Medicine
#3,290
of 3,958 outputs
Outputs of similar age
#220,286
of 243,272 outputs
Outputs of similar age from Journal of Translational Medicine
#44
of 45 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,958 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,272 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.