Title |
c-KIT receptor expression is strictly associated with the biological behaviour of thyroid nodules
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Published in |
Journal of Translational Medicine, January 2012
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DOI | 10.1186/1479-5876-10-7 |
Pubmed ID | |
Authors |
Sara Tomei, Chiara Mazzanti, Ivo Marchetti, Leonardo Rossi, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio, Generoso Bevilacqua |
Abstract |
A large amount of information has been collected on the molecular tumorigenesis of thyroid cancer. A low expression of c-KIT gene has been reported during the transformation of normal thyroid epithelium to papillary carcinoma suggesting a possible role of the gene in the differentiation of thyroid tissue rather than in the proliferation. The initial presentation of thyroid carcinoma is through a nodule and the best way nowadays to evaluate it is by fine-needle aspiration (FNA). However many thyroid FNAs are not definitively benign or malignant, yielding an indeterminate or suspicious diagnosis which ranges from 10 to 25% of FNAs. BRAF mutational analysis is commonly used to assess the malignancy of thyroid nodules but unfortunately it still leaves indeterminate diagnoses. The development of molecular initial diagnostic tests for evaluating a thyroid nodule is needed in order to define optimal surgical approach for patients with uncertain diagnosis pre- and intra-operatively. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 41% |
Student > Bachelor | 2 | 12% |
Student > Doctoral Student | 1 | 6% |
Lecturer > Senior Lecturer | 1 | 6% |
Student > Ph. D. Student | 1 | 6% |
Other | 3 | 18% |
Unknown | 2 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 29% |
Medicine and Dentistry | 5 | 29% |
Agricultural and Biological Sciences | 4 | 24% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Unknown | 2 | 12% |