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Mendeley readers
Attention Score in Context
| Title |
Latency: the hidden HIV-1 challenge
|
|---|---|
| Published in |
Retrovirology, January 2006
|
| DOI | 10.1186/1742-4690-3-7 |
| Pubmed ID | |
| Authors |
Alessandro Marcello |
| Abstract |
Eradication of HIV-1 from an infected individual cannot be achieved by current regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy for a long time and are able to replenish systemic infection upon interruption of the treatment. Therapeutic targeting of viral latency will require a better understanding of the basic mechanisms underlying the establishment and long-term maintenance of HIV-1 in resting memory CD4 T cells, the most prominent reservoir of transcriptionally silent provirus. Since the molecular mechanisms that permit long term transcriptional control of proviral gene expression in these cells are still obscure, this review aims at summarizing the various aspects of the problem that need to be considered. In particular, this review will focus the attention on the control of transcription imposed by chromatin through various epigenetic mechanisms. Exploring the molecular details of viral latency will provide new insights for eventual future therapeutics that aim at viral eradication. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 2% |
| Switzerland | 1 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| Canada | 1 | <1% |
| Argentina | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 93 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 31% |
| Researcher | 20 | 20% |
| Student > Master | 14 | 14% |
| Professor > Associate Professor | 6 | 6% |
| Student > Bachelor | 5 | 5% |
| Other | 15 | 15% |
| Unknown | 10 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 44% |
| Medicine and Dentistry | 19 | 19% |
| Immunology and Microbiology | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 9 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2016.
All research outputs
#4,572,822
of 22,675,759 outputs
Outputs from Retrovirology
#216
of 1,102 outputs
Outputs of similar age
#19,416
of 155,346 outputs
Outputs of similar age from Retrovirology
#2
of 11 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,102 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.