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Mendeley readers
Attention Score in Context
| Title |
Sodium ion channel mutations in glioblastoma patients correlate with shorter survival
|
|---|---|
| Published in |
Molecular Cancer, February 2011
|
| DOI | 10.1186/1476-4598-10-17 |
| Pubmed ID | |
| Authors |
Avadhut D Joshi, D Williams Parsons, Victor E Velculescu, Gregory J Riggins |
| Abstract |
Glioblastoma Multiforme (GBM) is the most common and invasive astrocytic tumor associated with dismal prognosis. Treatment for GBM patients has advanced, but the median survival remains a meager 15 months. In a recent study, 20,000 genes from 21 GBM patients were sequenced that identified frequent mutations in ion channel genes. The goal of this study was to determine whether ion channel mutations have a role in disease progression and whether molecular targeting of ion channels is a promising therapeutic strategy for GBM patients. Therefore, we compared GBM patient survival on the basis of presence or absence of mutations in calcium, potassium and sodium ion transport genes. Cardiac glycosides, known sodium channel inhibitors, were then tested for their ability to inhibit GBM cell proliferation. |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Chile | 1 | 1% |
| United States | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 66 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 19% |
| Researcher | 9 | 13% |
| Professor > Associate Professor | 7 | 10% |
| Student > Doctoral Student | 6 | 9% |
| Student > Bachelor | 6 | 9% |
| Other | 15 | 21% |
| Unknown | 14 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 24% |
| Medicine and Dentistry | 10 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Neuroscience | 5 | 7% |
| Engineering | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 19 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2012.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from Molecular Cancer
#1,472
of 1,714 outputs
Outputs of similar age
#173,154
of 184,042 outputs
Outputs of similar age from Molecular Cancer
#22
of 23 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,714 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,042 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.