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The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

Overview of attention for article published in BMC Medical Genetics, March 2012
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1 tweeter

Citations

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15 Dimensions

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48 Mendeley

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Title
The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro
Published in
BMC Medical Genetics, March 2012
DOI 10.1186/1471-2350-13-13
Pubmed ID
22397687
Authors

Elisabetta Tabolacci, Filomena Pirozzi, Baltazar Gomez-Mancilla, Fabrizio Gasparini, Giovanni Neri

Abstract

Fragile X syndrome (FXS), the leading cause of inherited mental retardation, is due to expansion and methylation of a CGG sequence in the FMR1 gene, which result in its silencing and consequent absence of FMRP protein. This absence causes loss of repression of metabotropic glutamate receptor 5 (mGluR5)-mediated pathways resulting in the behavioral and cognitive impairments associated with FXS. In a randomized, double-blind trial it was recently demonstrated a beneficial effect of AFQ056, a selective inhibitor of metabotrobic glutamate receptor type 5 (mGluR5), on fully methylated FXS patients respect to partially methylated FXS ones.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 19%
Student > Ph. D. Student 6 13%
Student > Bachelor 5 10%
Other 4 8%
Professor 3 6%
Other 12 25%
Unknown 9 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 27%
Medicine and Dentistry 7 15%
Biochemistry, Genetics and Molecular Biology 6 13%
Neuroscience 6 13%
Nursing and Health Professions 1 2%
Other 5 10%
Unknown 10 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2012.
All research outputs
#15,249,959
of 22,675,759 outputs
Outputs from BMC Medical Genetics
#516
of 1,029 outputs
Outputs of similar age
#99,984
of 156,195 outputs
Outputs of similar age from BMC Medical Genetics
#7
of 15 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,029 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,195 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.

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