Searching for mechanisms that matter in early septic acute kidney injury: an experimental study

Jan Benes, Jiri Chvojka, Roman Sykora, Jaroslav Radej, Ales Krouzecky, Ivan Novak, Martin Matejovic

In almost half of all sepsis patients, acute kidney injury (AKI) develops. However, the pathobiologic differences between sepsis patients with and without AKI are only poorly understood. We used a unique opportunity to examine dynamic inflammatory, renal hemodynamic, and microvascular changes in two clinically relevant large-animal models of sepsis. Our aim was to assess variability in renal responses to sepsis and to identify both hemodynamic and nonhemodynamic mechanisms discriminating individuals with AKI from those in whom AKI did not develop.