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Reduced graphene oxide: nanotoxicological profile in rats

Overview of attention for article published in Journal of Nanobiotechnology, June 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
1 news outlet
twitter
2 tweeters
wikipedia
1 Wikipedia page
reddit
1 Redditor

Citations

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52 Dimensions

Readers on

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60 Mendeley
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Title
Reduced graphene oxide: nanotoxicological profile in rats
Published in
Journal of Nanobiotechnology, June 2016
DOI 10.1186/s12951-016-0206-9
Pubmed ID
Authors

Monique Culturato Padilha Mendonça, Edilene Siqueira Soares, Marcelo Bispo de Jesus, Helder José Ceragioli, Silvia Pierre Irazusta, Ângela Giovana Batista, Marco Aurélio Ramirez Vinolo, Mário Roberto Maróstica Júnior, Maria Alice da Cruz-Höfling

Abstract

We have previously demonstrated that reduced graphene oxide (rGO) administered intravenously in rats was detected inside the hippocampus after downregulation of the tight and adherens junction proteins of the blood-brain barrier. While down-regulators of junctional proteins could be useful tools for drug delivery through the paracellular pathway, concerns over toxicity must be investigated before clinical application. Herein, our purpose was to trace whether the rGO inside the hippocampus triggered toxic alterations in this brain region and in target organs (blood, liver and kidney) of rats at various time points (15 min, 1, 3 h and 7 days). The assessed rGO-treated rats (7 mg/kg) were clinically indistinguishable from controls at all the time points. Hematological, histopathological (neurons and astrocytes markers), biochemical (nephrotoxicity and hepatotoxicity assessment) and genotoxicological based tests showed that systemic rGO single injection seemed to produce minimal toxicological effects at the time points assessed. Relative to control, the only change was a decrease in the blood urea nitrogen level 3 h post-treatment and increases in superoxide dismutase activity 1 h and 7 days post-treatment. While no alteration in leukocyte parameters was detected between control and rGO-treated animals, time-dependent leukocytosis (rGO-1 h versus rGO-3 h) and leukopenia (rGO-3 h versus rGO-7 days) was observed intra-treated groups. Nevertheless, no inflammatory response was induced in serum and hippocampus at any time. The toxic effects seemed to be peripheral and transitory in the short-term analysis after systemic administration of rGO. The effects were self-limited and non-significant even at 7 days post-rGO administration.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 17%
Student > Master 9 15%
Student > Bachelor 9 15%
Researcher 6 10%
Student > Doctoral Student 4 7%
Other 9 15%
Unknown 13 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 13%
Pharmacology, Toxicology and Pharmaceutical Science 7 12%
Neuroscience 6 10%
Medicine and Dentistry 5 8%
Agricultural and Biological Sciences 3 5%
Other 13 22%
Unknown 18 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2021.
All research outputs
#2,057,964
of 22,879,161 outputs
Outputs from Journal of Nanobiotechnology
#57
of 1,424 outputs
Outputs of similar age
#39,325
of 352,727 outputs
Outputs of similar age from Journal of Nanobiotechnology
#2
of 16 outputs
Altmetric has tracked 22,879,161 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,424 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,727 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.