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Broadly reactive antibodies specific for Plasmodium falciparum MSP-119 are associated with the protection of naturally exposed children against infection

Overview of attention for article published in Malaria Journal, August 2012
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Title
Broadly reactive antibodies specific for Plasmodium falciparum MSP-119 are associated with the protection of naturally exposed children against infection
Published in
Malaria Journal, August 2012
DOI 10.1186/1475-2875-11-287
Pubmed ID
Authors

Arlene E Dent, Ann M Moormann, Christopher T Yohn, Rhonda J Kimmel, Peter O Sumba, John Vulule, Carole A Long, David L Narum, Brendan S Crabb, James W Kazura, Daniel J Tisch

Abstract

The 19 kDa C-terminal region of Plasmodium falciparum Merozoite Surface Protein-1 is a known target of naturally acquired humoral immunity and a malaria vaccine candidate. MSP-119 has four predominant haplotypes resulting in amino acid changes labelled EKNG, QKNG, QTSR and ETSR. IgG antibodies directed against all four variants have been detected, but it is not known if these variant specific antibodies are associated with haplotype-specific protection from infection.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 22%
Student > Master 8 22%
Student > Ph. D. Student 6 17%
Student > Bachelor 4 11%
Student > Doctoral Student 2 6%
Other 7 19%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 25%
Medicine and Dentistry 7 19%
Biochemistry, Genetics and Molecular Biology 6 17%
Immunology and Microbiology 4 11%
Economics, Econometrics and Finance 2 6%
Other 4 11%
Unknown 4 11%