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Direct integration of intensity-level data from Affymetrix and Illumina microarrays improves statistical power for robust reanalysis

Overview of attention for article published in BMC Medical Genomics, August 2012
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Title
Direct integration of intensity-level data from Affymetrix and Illumina microarrays improves statistical power for robust reanalysis
Published in
BMC Medical Genomics, August 2012
DOI 10.1186/1755-8794-5-35
Pubmed ID
Authors

Arran K Turnbull, Robert R Kitchen, Alexey A Larionov, Lorna Renshaw, J Michael Dixon, Andrew H Sims

Abstract

Affymetrix GeneChips and Illumina BeadArrays are the most widely used commercial single channel gene expression microarrays. Public data repositories are an extremely valuable resource, providing array-derived gene expression measurements from many thousands of experiments. Unfortunately many of these studies are underpowered and it is desirable to improve power by combining data from more than one study; we sought to determine whether platform-specific bias precludes direct integration of probe intensity signals for combined reanalysis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
Germany 1 <1%
Brazil 1 <1%
Ukraine 1 <1%
Taiwan 1 <1%
United States 1 <1%
Unknown 94 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 25%
Researcher 21 21%
Student > Master 15 15%
Student > Bachelor 6 6%
Other 5 5%
Other 17 17%
Unknown 12 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 26%
Biochemistry, Genetics and Molecular Biology 18 18%
Medicine and Dentistry 15 15%
Computer Science 10 10%
Engineering 5 5%
Other 10 10%
Unknown 17 17%