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CAP protein superfamily members in Toxocara canis

Overview of attention for article published in Parasites & Vectors, June 2016
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Title
CAP protein superfamily members in Toxocara canis
Published in
Parasites & Vectors, June 2016
DOI 10.1186/s13071-016-1642-y
Pubmed ID
Authors

Andreas J. Stroehlein, Neil D. Young, Ross S. Hall, Pasi K. Korhonen, Andreas Hofmann, Paul W. Sternberg, Abdul Jabbar, Robin B. Gasser

Abstract

Proteins of the cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 (CAP) superfamily are recognized or proposed to play roles in parasite development and reproduction, and in modulating host immune attack and infection processes. However, little is known about these proteins for most parasites. In the present study, we explored CAP proteins of Toxocara canis, a socioeconomically important zoonotic roundworm. To do this, we mined and curated transcriptomic and genomic data, predicted and curated full-length protein sequences (n = 28), conducted analyses of these data and studied the transcription of respective genes in different developmental stages of T. canis. In addition, based on information available for Caenorhabditis elegans, we inferred that selected genes (including lon-1, vap-1, vap-2, scl-1, scl-8 and scl-11 orthologs) of T. canis and their interaction partners likely play central roles in this parasite's development and/or reproduction via TGF-beta and/or insulin-like signaling pathways, or via host interactions. In conclusion, this study could provide a foundation to guide future studies of CAP proteins of T. canis and related parasites, and might assist in finding new interventions against diseases caused by these parasites.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 22%
Researcher 3 13%
Student > Postgraduate 3 13%
Student > Master 3 13%
Student > Doctoral Student 1 4%
Other 4 17%
Unknown 4 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 26%
Agricultural and Biological Sciences 4 17%
Immunology and Microbiology 3 13%
Sports and Recreations 1 4%
Unknown 9 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2016.
All research outputs
#14,484,934
of 23,298,349 outputs
Outputs from Parasites & Vectors
#2,840
of 5,548 outputs
Outputs of similar age
#202,539
of 354,293 outputs
Outputs of similar age from Parasites & Vectors
#97
of 176 outputs
Altmetric has tracked 23,298,349 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,548 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,293 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 176 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.