Title |
Pathogenicity of reassortant H9 influenza viruses with different NA genes in mice and chickens
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Published in |
Veterinary Research, June 2016
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DOI | 10.1186/s13567-016-0352-y |
Pubmed ID | |
Authors |
Liping Yan, Qinfang Liu, Xin Su, Qiaoyang Teng, Danqi Bao, Guangsheng Che, Hongjun Chen, Hongrui Cui, Tao Ruan, Xuesong Li, Zejun Li |
Abstract |
To better understand the influence of different NA genes on pathogenicity of H9 viruses, three reassortant H9 viruses (rH9N1, H9N2 and rH9N3) were generated and characterized. All three viruses replicated efficiently in eggs and MDCK cells, whereas the rH9N1 and rH9N3 replicated more efficiently than H9N2 in A549 cells. The rH9N3 replicated more efficiently than rH9N1 and H9N2 viruses in mice, however, rH9N3 replicated and shed less efficiently than the H9N2 virus in chickens. Further studies indicate that N3 had higher NA activity and released virus from erythrocytes faster, which may improve the adaptation of H9 influenza virus to mammals. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 25% |
Student > Ph. D. Student | 3 | 19% |
Student > Master | 3 | 19% |
Unspecified | 1 | 6% |
Professor > Associate Professor | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 31% |
Immunology and Microbiology | 4 | 25% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Unspecified | 1 | 6% |
Other | 1 | 6% |
Unknown | 2 | 13% |