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Engineering approaches for regeneration of T lymphopoiesis

Overview of attention for article published in Biomaterials Research, June 2016
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Title
Engineering approaches for regeneration of T lymphopoiesis
Published in
Biomaterials Research, June 2016
DOI 10.1186/s40824-016-0067-1
Pubmed ID
Authors

Kyung-Ho Roh, Krishnendu Roy

Abstract

T cells play a central role in immune-homeostasis; specifically in the induction of antigen-specific adaptive immunity against pathogens and mutated self with immunological memory. The thymus is the unique organ where T cells are generated. In this review, first the complex structures and functions of various thymic microcompartments are briefly discussed to identify critical engineering targets for regeneration of thymic functions in vitro and in vivo. Then the biomimetic regenerative engineering approaches are reviewed in three categories: 1) reconstruction of 3-D thymic architecture, 2) cellular engineering, and 3) biomaterials-based artificial presentation of critical biomolecules. For each engineering approach, remaining challenges and clinical opportunities are also identified and discussed.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 34%
Student > Master 8 20%
Student > Bachelor 3 7%
Professor 3 7%
Researcher 3 7%
Other 5 12%
Unknown 5 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 22%
Immunology and Microbiology 7 17%
Biochemistry, Genetics and Molecular Biology 5 12%
Medicine and Dentistry 4 10%
Chemical Engineering 3 7%
Other 6 15%
Unknown 7 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2016.
All research outputs
#22,759,802
of 25,374,647 outputs
Outputs from Biomaterials Research
#158
of 197 outputs
Outputs of similar age
#323,488
of 367,294 outputs
Outputs of similar age from Biomaterials Research
#9
of 10 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 197 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,294 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.