Title |
Engineering approaches for regeneration of T lymphopoiesis
|
---|---|
Published in |
Biomaterials Research, June 2016
|
DOI | 10.1186/s40824-016-0067-1 |
Pubmed ID | |
Authors |
Kyung-Ho Roh, Krishnendu Roy |
Abstract |
T cells play a central role in immune-homeostasis; specifically in the induction of antigen-specific adaptive immunity against pathogens and mutated self with immunological memory. The thymus is the unique organ where T cells are generated. In this review, first the complex structures and functions of various thymic microcompartments are briefly discussed to identify critical engineering targets for regeneration of thymic functions in vitro and in vivo. Then the biomimetic regenerative engineering approaches are reviewed in three categories: 1) reconstruction of 3-D thymic architecture, 2) cellular engineering, and 3) biomaterials-based artificial presentation of critical biomolecules. For each engineering approach, remaining challenges and clinical opportunities are also identified and discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 34% |
Student > Master | 8 | 20% |
Student > Bachelor | 3 | 7% |
Professor | 3 | 7% |
Researcher | 3 | 7% |
Other | 5 | 12% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 22% |
Immunology and Microbiology | 7 | 17% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Medicine and Dentistry | 4 | 10% |
Chemical Engineering | 3 | 7% |
Other | 6 | 15% |
Unknown | 7 | 17% |