Title |
Long-term effects of cranial irradiation and intrathecal chemotherapy in treatment of childhood leukemia: a MEG study of power spectrum and correlated cognitive dysfunction
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Published in |
BMC Neurology, August 2012
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DOI | 10.1186/1471-2377-12-84 |
Pubmed ID | |
Authors |
Marita Daams, Ilse Schuitema, Bob W van Dijk, Eline van Dulmen-den Broeder, Anjo JP Veerman, Cor van den Bos, Leo MJ de Sonneville |
Abstract |
Prophylaxis to prevent relapses in the central nervous system after childhood acute lymphoblastic leukemia (ALL) used to consist of both intrathecal chemotherapy (CT) and cranial irradiation (CRT). CRT was mostly abolished in the eighties because of its neurotoxicity, and replaced with more intensive intrathecal CT. In this study, a group of survivors treated with CRT before 1983 and another group treated without CRT thereafter are investigated 20-25 years later, giving a much stronger perspective on long-term quality of life than previous studies. The outcomes will help to better understand these groups' current needs and will aid in anticipating late effects of prophylactic CRT that is currently applied for other diseases. This study evaluates oscillatory neuronal activity in these long-term survivors. Power spectrum deviations are hypothesized to correlate with cognitive dysfunction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Egypt | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Netherlands | 2 | 2% |
Brazil | 1 | <1% |
Unknown | 111 | 97% |
Demographic breakdown
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Student > Ph. D. Student | 17 | 15% |
Student > Master | 16 | 14% |
Researcher | 14 | 12% |
Student > Bachelor | 9 | 8% |
Student > Doctoral Student | 8 | 7% |
Other | 26 | 23% |
Unknown | 24 | 21% |
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Psychology | 26 | 23% |
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Neuroscience | 6 | 5% |
Social Sciences | 4 | 4% |
Other | 15 | 13% |
Unknown | 27 | 24% |