Title |
Negative studies are helpful to compute the specificity of diagnostic tests: measuring Trypanosoma cruzi seroprevalence in Guanajuato, Mexico
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Published in |
BMC Research Notes, October 2015
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DOI | 10.1186/s13104-015-1612-z |
Pubmed ID | |
Authors |
Nicolás Padilla-Raygoza, Rubí Gamboa-León, Maria Jesus Ramirez-Sierra, Eric Dumonteil, Pierre Buekens, Ma Laura Ruiz-Paloalto, Rosalina Diaz-Guerrero |
Abstract |
Publishing negative seroprevalence studies not only helps to have more accurate seroprevalence estimates but also allows calculating the specificity of the diagnostic tests used. We performed a population-based Trypanosoma cruzi seroprevalence survey in a community in central Mexico. We surveyed 204 women and children and collected blood by finger prick. We performed rapid tests (Stat-Pak, Chembio, Inc., Medford, New York) and recombinant Chagas ELISA tests v3.0 (Wiener, Rosario, Argentina). All rapid tests and all ELISA tests were negative. The rapid test had 100 % of specificity compared to the ELISA. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 25% |
Student > Master | 4 | 20% |
Student > Doctoral Student | 3 | 15% |
Student > Ph. D. Student | 2 | 10% |
Other | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 20% |
Agricultural and Biological Sciences | 3 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
Immunology and Microbiology | 2 | 10% |
Environmental Science | 1 | 5% |
Other | 4 | 20% |
Unknown | 4 | 20% |