@jwoodgett @DanielJDrucker Also powerful synthetic lethals, while neither isoform shows a severe knockout fitness phenotype anywhere. Clear cut case of functional buffering. https://t.co/js9cHzoOsS
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RT @NCIgenomics: Reconciling the low number of essential genes—and candidate cancer targets—detected in #CRISPR knockout screens by conside…
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You've read her work on using enAsCas12a multiplex screens to reveal functional buffering by paralogs, a blind spot in Cas9 knockout fitness screens https://t.co/js9cHzGpRs
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We next integrated all of these in a classifier to make predictions for all human paralog pairs and found that our predictions could accurately predict the results of combinatorial CRISPR screens (such as the recent work of @TraverHart and @drmervedede ht