Title |
Two new Rett syndrome families and review of the literature: expanding the knowledge of MECP2 frameshift mutations
|
---|---|
Published in |
Orphanet Journal of Rare Diseases, August 2011
|
DOI | 10.1186/1750-1172-6-58 |
Pubmed ID | |
Authors |
Kirstine Ravn, Gitte Roende, Morten Duno, Kathrine Fuglsang, Kristin L Eiklid, Zeynep Tümer, Jytte B Nielsen, Ola H Skjeldal |
Abstract |
Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder, which is usually caused by de novo mutations in the MECP2 gene. More than 70% of the disease causing MECP2 mutations are eight recurrent C to T transitions, which almost exclusively arise on the paternally derived X chromosome. About 10% of the RTT cases have a C-terminal frameshift deletion in MECP2. Only few RTT families with a segregating MECP2 mutation, which affects female carriers with a phenotype of mental retardation or RTT, have been reported in the literature. In this study we describe two new RTT families with three and four individuals, respectively, and review the literature comparing the type of mutations and phenotypes observed in RTT families with those observed in sporadic cases. Based on these observations we also investigated origin of mutation segregation to further improve genetic counselling. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 2% |
Unknown | 46 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 21% |
Student > Bachelor | 9 | 19% |
Researcher | 6 | 13% |
Student > Master | 6 | 13% |
Other | 4 | 9% |
Other | 7 | 15% |
Unknown | 5 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 26% |
Agricultural and Biological Sciences | 11 | 23% |
Biochemistry, Genetics and Molecular Biology | 9 | 19% |
Neuroscience | 3 | 6% |
Social Sciences | 2 | 4% |
Other | 4 | 9% |
Unknown | 6 | 13% |