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Inference of gene regulatory networks from time series by Tsallis entropy

Overview of attention for article published in BMC Systems Biology, May 2011
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Title
Inference of gene regulatory networks from time series by Tsallis entropy
Published in
BMC Systems Biology, May 2011
DOI 10.1186/1752-0509-5-61
Pubmed ID
Authors

Fabrício Martins Lopes, Evaldo A de Oliveira, Roberto M Cesar

Abstract

The inference of gene regulatory networks (GRNs) from large-scale expression profiles is one of the most challenging problems of Systems Biology nowadays. Many techniques and models have been proposed for this task. However, it is not generally possible to recover the original topology with great accuracy, mainly due to the short time series data in face of the high complexity of the networks and the intrinsic noise of the expression measurements. In order to improve the accuracy of GRNs inference methods based on entropy (mutual information), a new criterion function is here proposed.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 4%
United Kingdom 2 3%
France 1 1%
Denmark 1 1%
United States 1 1%
Unknown 65 89%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 25%
Researcher 15 21%
Student > Ph. D. Student 15 21%
Professor > Associate Professor 5 7%
Student > Bachelor 4 5%
Other 11 15%
Unknown 5 7%
Readers by discipline Count As %
Computer Science 23 32%
Agricultural and Biological Sciences 17 23%
Biochemistry, Genetics and Molecular Biology 9 12%
Physics and Astronomy 8 11%
Engineering 5 7%
Other 5 7%
Unknown 6 8%