Title |
Synthesis of an antiviral drug precursor from chitin using a saprophyte as a whole-cell catalyst
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Published in |
Microbial Cell Factories, December 2011
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DOI | 10.1186/1475-2859-10-102 |
Pubmed ID | |
Authors |
Matthias G Steiger, Astrid R Mach-Aigner, Rita Gorsche, Erwin E Rosenberg, Marko D Mihovilovic, Robert L Mach |
Abstract |
Recent incidents, such as the SARS and influenza epidemics, have highlighted the need for readily available antiviral drugs. One important precursor currently used for the production of Relenza, an antiviral product from GlaxoSmithKline, is N-acetylneuraminic acid (NeuNAc). This substance has a considerably high market price despite efforts to develop cost-reducing (biotechnological) production processes. Hypocrea jecorina (Trichoderma reesei) is a saprophyte noted for its abundant secretion of hydrolytic enzymes and its potential to degrade chitin to its monomer N-acetylglucosamine (GlcNAc). Chitin is considered the second most abundant biomass available on earth and therefore an attractive raw material. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 23% |
Lecturer | 5 | 13% |
Professor | 4 | 10% |
Student > Doctoral Student | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 7 | 18% |
Unknown | 9 | 23% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 23% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Immunology and Microbiology | 2 | 5% |
Chemistry | 2 | 5% |
Economics, Econometrics and Finance | 2 | 5% |
Other | 4 | 10% |
Unknown | 16 | 40% |