Title |
Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumors
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Published in |
BMC Clinical Pathology, September 2012
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DOI | 10.1186/1472-6890-12-14 |
Pubmed ID | |
Authors |
Florence Brellier, Enrico Martina, Martin Degen, Nathalie Heuzé-Vourc’h, Agnès Petit, Thomas Kryza, Yves Courty, Luigi Terracciano, Christian Ruiz, Ruth Chiquet-Ehrismann |
Abstract |
Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid tumors have not been analyzed. The present study was undertaken to determine whether tenascin-W could serve as a cancer-specific extracellular matrix protein in a broad range of solid tumors. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 2% |
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Demographic breakdown
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Researcher | 7 | 16% |
Student > Ph. D. Student | 6 | 14% |
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