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Functional analysis of transcription factor binding sites in human promoters

Overview of attention for article published in Genome Biology, September 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

blogs
2 blogs
twitter
3 X users
q&a
1 Q&A thread

Citations

dimensions_citation
134 Dimensions

Readers on

mendeley
665 Mendeley
citeulike
7 CiteULike
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Title
Functional analysis of transcription factor binding sites in human promoters
Published in
Genome Biology, September 2012
DOI 10.1186/gb-2012-13-9-r50
Pubmed ID
Authors

Troy W Whitfield, Jie Wang, Patrick J Collins, E Christopher Partridge, Shelley Force Aldred, Nathan D Trinklein, Richard M Myers, Zhiping Weng

Abstract

The binding of transcription factors to specific locations in the genome is integral to the orchestration of transcriptional regulation in cells. To characterize transcription factor binding site function on a large scale, we predicted and mutagenized 455 binding sites in human promoters. We carried out functional tests on these sites in four different immortalized human cell lines using transient transfections with a luciferase reporter assay, primarily for the transcription factors CTCF, GABP, GATA2, E2F, STAT, and YY1.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 665 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 22 3%
United States 19 3%
Germany 5 <1%
France 4 <1%
Spain 4 <1%
China 3 <1%
Brazil 3 <1%
Poland 2 <1%
Australia 2 <1%
Other 16 2%
Unknown 585 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 211 32%
Researcher 173 26%
Student > Master 75 11%
Student > Bachelor 42 6%
Professor > Associate Professor 30 5%
Other 89 13%
Unknown 45 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 373 56%
Biochemistry, Genetics and Molecular Biology 116 17%
Computer Science 37 6%
Medicine and Dentistry 31 5%
Engineering 10 2%
Other 42 6%
Unknown 56 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2014.
All research outputs
#2,082,139
of 25,374,917 outputs
Outputs from Genome Biology
#1,763
of 4,467 outputs
Outputs of similar age
#13,530
of 187,002 outputs
Outputs of similar age from Genome Biology
#24
of 56 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,002 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.