For certain TFs, these sites of a common mutation (i.e. common alternative) reside in highly-conserved genomic regions. We speculate that this local conservation compensates for the motif weakness. A related observation was made for human CTCF https://t.co
Rereading 'Analysis of variation at transcription factor binding sites in Drosophila and humans' (Genome Biology) http://t.co/HZ8YR1O2f2
Analysis of variation at transcription factor binding sites in Drosophila and humans. http://t.co/U4nlIL07
MT @ewanbirney: EBI postdoc Mikhail Spivakov led on this interesting paper about TF binding <-> variation in human+fly http://t.co/mayonnfR