Title |
Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)
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Published in |
BMC Pediatrics, September 2012
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DOI | 10.1186/1471-2431-12-144 |
Pubmed ID | |
Authors |
Luca Filippi, Patrizio Fiorini, Marta Daniotti, Serena Catarzi, Sara Savelli, Claudio Fonda, Laura Bartalena, Antonio Boldrini, Matteo Giampietri, Rosa Scaramuzzo, Paola Papoff, Francesca Del Balzo, Alberto Spalice, Giancarlo la Marca, Sabrina Malvagia, Maria Luisa Della Bona, Gianpaolo Donzelli, Francesca Tinelli, Giovanni Cioni, Tiziana Pisano, Melania Falchi, Renzo Guerrini |
Abstract |
Despite progresses in neonatal care, the mortality and the incidence of neuro-motor disability after perinatal asphyxia have failed to show substantial improvements. In countries with a high level of perinatal care, the incidence of asphyxia responsible for moderate or severe encephalopathy is still 2-3 per 1000 term newborns. Recent trials have demonstrated that moderate hypothermia, started within 6 hours after birth and protracted for 72 hours, can significantly improve survival and reduce neurologic impairment in neonates with hypoxic-ischemic encephalopathy. It is not currently known whether neuroprotective drugs can further improve the beneficial effects of hypothermia. Topiramate has been proven to reduce brain injury in animal models of neonatal hypoxic ischemic encephalopathy. However, the association of mild hypothermia and topiramate treatment has never been studied in human newborns. The objective of this research project is to evaluate, through a multicenter randomized controlled trial, whether the efficacy of moderate hypothermia can be increased by concomitant topiramate treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | <1% |
France | 1 | <1% |
Canada | 1 | <1% |
Korea, Republic of | 1 | <1% |
United States | 1 | <1% |
Unknown | 121 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 15% |
Student > Master | 16 | 13% |
Student > Ph. D. Student | 10 | 8% |
Other | 8 | 6% |
Student > Postgraduate | 8 | 6% |
Other | 27 | 21% |
Unknown | 38 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 47 | 37% |
Neuroscience | 9 | 7% |
Nursing and Health Professions | 6 | 5% |
Psychology | 6 | 5% |
Social Sciences | 4 | 3% |
Other | 14 | 11% |
Unknown | 40 | 32% |