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Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)

Overview of attention for article published in BMC Pediatrics, September 2012
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Title
Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)
Published in
BMC Pediatrics, September 2012
DOI 10.1186/1471-2431-12-144
Pubmed ID
Authors

Luca Filippi, Patrizio Fiorini, Marta Daniotti, Serena Catarzi, Sara Savelli, Claudio Fonda, Laura Bartalena, Antonio Boldrini, Matteo Giampietri, Rosa Scaramuzzo, Paola Papoff, Francesca Del Balzo, Alberto Spalice, Giancarlo la Marca, Sabrina Malvagia, Maria Luisa Della Bona, Gianpaolo Donzelli, Francesca Tinelli, Giovanni Cioni, Tiziana Pisano, Melania Falchi, Renzo Guerrini

Abstract

Despite progresses in neonatal care, the mortality and the incidence of neuro-motor disability after perinatal asphyxia have failed to show substantial improvements. In countries with a high level of perinatal care, the incidence of asphyxia responsible for moderate or severe encephalopathy is still 2-3 per 1000 term newborns. Recent trials have demonstrated that moderate hypothermia, started within 6 hours after birth and protracted for 72 hours, can significantly improve survival and reduce neurologic impairment in neonates with hypoxic-ischemic encephalopathy. It is not currently known whether neuroprotective drugs can further improve the beneficial effects of hypothermia. Topiramate has been proven to reduce brain injury in animal models of neonatal hypoxic ischemic encephalopathy. However, the association of mild hypothermia and topiramate treatment has never been studied in human newborns. The objective of this research project is to evaluate, through a multicenter randomized controlled trial, whether the efficacy of moderate hypothermia can be increased by concomitant topiramate treatment.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
France 1 <1%
Canada 1 <1%
Korea, Republic of 1 <1%
United States 1 <1%
Unknown 121 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 15%
Student > Master 16 13%
Student > Ph. D. Student 10 8%
Other 8 6%
Student > Postgraduate 8 6%
Other 27 21%
Unknown 38 30%
Readers by discipline Count As %
Medicine and Dentistry 47 37%
Neuroscience 9 7%
Nursing and Health Professions 6 5%
Psychology 6 5%
Social Sciences 4 3%
Other 14 11%
Unknown 40 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2015.
All research outputs
#13,871,657
of 22,678,224 outputs
Outputs from BMC Pediatrics
#1,742
of 2,975 outputs
Outputs of similar age
#96,310
of 169,211 outputs
Outputs of similar age from BMC Pediatrics
#27
of 51 outputs
Altmetric has tracked 22,678,224 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,975 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,211 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.