Title |
miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer
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Published in |
BMC Medical Genomics, September 2012
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DOI | 10.1186/1755-8794-5-40 |
Pubmed ID | |
Authors |
Iver Nordentoft, Karin Birkenkamp-Demtroder, Mads Agerbæk, Dan Theodorescu, Marie Stampe Ostenfeld, Arndt Hartmann, Michael Borre, Torben F Ørntoft, Lars Dyrskjøt |
Abstract |
MicroRNA is a naturally occurring class of non-coding RNA molecules that mediate posttranscriptional gene regulation and are strongly implicated in cellular processes such as cell proliferation, carcinogenesis, cell survival and apoptosis. Consequently there is increasing focus on miRNA expression as prognostic factors for outcome and chemotherapy response. Only approximately 50% of patients with bladder cancer respond to chemotherapy. Therefore, predictive markers, such as miRNAs, that can identify subgroups of patients who will benefit from chemotherapy will have great value for treatment guidance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 35% |
Student > Master | 9 | 19% |
Student > Ph. D. Student | 6 | 13% |
Student > Doctoral Student | 4 | 8% |
Student > Bachelor | 3 | 6% |
Other | 4 | 8% |
Unknown | 5 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 38% |
Medicine and Dentistry | 10 | 21% |
Biochemistry, Genetics and Molecular Biology | 9 | 19% |
Nursing and Health Professions | 1 | 2% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 2 | 4% |
Unknown | 7 | 15% |