Title |
Rotavirus A-specific single-domain antibodies produced in baculovirus-infected insect larvae are protective in vivo
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Published in |
BMC Biotechnology, September 2012
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DOI | 10.1186/1472-6750-12-59 |
Pubmed ID | |
Authors |
Silvia Gómez-Sebastián, Maria C Nuñez, Lorena Garaicoechea, Carmen Alvarado, Marina Mozgovoj, Rodrigo Lasa, Alan Kahl, Andres Wigdorovitz, Viviana Parreño, José M Escribano |
Abstract |
Single-domain antibodies (sdAbs), also known as nanobodies or VHHs, are characterized by high stability and solubility, thus maintaining the affinity and therapeutic value provided by conventional antibodies. Given these properties, VHHs offer a novel alternative to classical antibody approaches. To date, VHHs have been produced mainly in E. coli, yeast, plants and mammalian cells. To apply the single-domain antibodies as a preventive or therapeutic strategy to control rotavirus infections in developing countries (444,000 deaths in children under 5 years of age) has to be minimized their production costs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 1% |
Brazil | 1 | 1% |
South Africa | 1 | 1% |
Canada | 1 | 1% |
Argentina | 1 | 1% |
Unknown | 79 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 26 | 31% |
Student > Ph. D. Student | 13 | 15% |
Student > Master | 11 | 13% |
Student > Bachelor | 8 | 10% |
Student > Doctoral Student | 3 | 4% |
Other | 9 | 11% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 32% |
Biochemistry, Genetics and Molecular Biology | 13 | 15% |
Medicine and Dentistry | 5 | 6% |
Immunology and Microbiology | 4 | 5% |
Veterinary Science and Veterinary Medicine | 3 | 4% |
Other | 14 | 17% |
Unknown | 18 | 21% |