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Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation

Overview of attention for article published in Journal of Neuroinflammation, March 2012
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  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

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2 X users
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2 Facebook pages
video
3 YouTube creators

Citations

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75 Dimensions

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58 Mendeley
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Title
Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation
Published in
Journal of Neuroinflammation, March 2012
DOI 10.1186/1742-2094-9-51
Pubmed ID
Authors

Mahmoud L Soliman, Mark D Smith, Heidi M Houdek, Thad A Rosenberger

Abstract

Long-term acetate supplementation reduces neuroglial activation and cholinergic cell loss in a rat model of lipopolysaccharide-induced neuroinflammation. Additionally, a single dose of glyceryl triacetate, used to induce acetate supplementation, increases histone H3 and H4 acetylation and inhibits histone deacetylase activity and histone deacetylase-2 expression in normal rat brain. Here, we propose that the therapeutic effect of acetate in reducing neuroglial activation is due to a reversal of lipopolysaccharide-induced changes in histone acetylation and pro-inflammatory cytokine expression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Argentina 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 26%
Researcher 10 17%
Student > Bachelor 6 10%
Student > Master 5 9%
Professor > Associate Professor 3 5%
Other 6 10%
Unknown 13 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 31%
Biochemistry, Genetics and Molecular Biology 7 12%
Medicine and Dentistry 6 10%
Neuroscience 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 6 10%
Unknown 16 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2022.
All research outputs
#13,431,543
of 22,797,621 outputs
Outputs from Journal of Neuroinflammation
#1,444
of 2,628 outputs
Outputs of similar age
#87,815
of 156,792 outputs
Outputs of similar age from Journal of Neuroinflammation
#13
of 32 outputs
Altmetric has tracked 22,797,621 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,628 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,792 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.