Title |
Thalidomide and its analogues in the treatment of Multiple Myeloma
|
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Published in |
Experimental Hematology & Oncology, September 2012
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DOI | 10.1186/2162-3619-1-27 |
Pubmed ID | |
Authors |
Tahir Latif, Nabeel Chauhan, Rashid Khan, Andrea Moran, Saad Z Usmani |
Abstract |
Multiple myeloma is an incurable malignant disorder of mature B-cells that predominantly affects the elderly. The immunomodulatory drug (IMiD) thalidomide and its newer analogs demonstrate increased antitumor activity, and have had a positive impact on the natural history of multiple myeloma. Recent advances in the clinical application of these agents and in our understanding of their mechanism of action, and toxicity have made safer and smarter use of these drugs possible. This review discusses the available information regarding mechanisms of action, toxicity and clinical results on thalidomide, lenalidomide and pomalidomide in the therapy of multiple myeloma. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
United Kingdom | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 103 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 16 | 15% |
Researcher | 12 | 12% |
Student > Ph. D. Student | 10 | 10% |
Student > Master | 9 | 9% |
Other | 7 | 7% |
Other | 15 | 14% |
Unknown | 35 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 22% |
Biochemistry, Genetics and Molecular Biology | 15 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 10% |
Agricultural and Biological Sciences | 9 | 9% |
Chemistry | 7 | 7% |
Other | 8 | 8% |
Unknown | 32 | 31% |