Title |
Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue
|
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Published in |
Journal of Translational Medicine, June 2012
|
DOI | 10.1186/1479-5876-10-125 |
Pubmed ID | |
Authors |
David J Monsma, Noel R Monks, David M Cherba, Dawna Dylewski, Emily Eugster, Hailey Jahn, Sujata Srikanth, Stephanie B Scott, Patrick J Richardson, Robin E Everts, Aleksandr Ishkin, Yuri Nikolsky, James H Resau, Robert Sigler, Brian J Nickoloff, Craig P Webb |
Abstract |
There is resurgence within drug and biomarker development communities for the use of primary tumorgraft models as improved predictors of patient tumor response to novel therapeutic strategies. Despite perceived advantages over cell line derived xenograft models, there is limited data comparing the genotype and phenotype of tumorgrafts to the donor patient tumor, limiting the determination of molecular relevance of the tumorgraft model. This report directly compares the genomic characteristics of patient tumors and the derived tumorgraft models, including gene expression, and oncogenic mutation status. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 5% |
France | 1 | 1% |
Unknown | 77 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 24 | 29% |
Student > Ph. D. Student | 16 | 20% |
Student > Master | 7 | 9% |
Professor > Associate Professor | 6 | 7% |
Student > Bachelor | 4 | 5% |
Other | 11 | 13% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 26% |
Agricultural and Biological Sciences | 19 | 23% |
Biochemistry, Genetics and Molecular Biology | 15 | 18% |
Engineering | 5 | 6% |
Neuroscience | 3 | 4% |
Other | 7 | 9% |
Unknown | 12 | 15% |