Title |
Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains
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Published in |
BMC Genomics, September 2012
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DOI | 10.1186/1471-2164-13-476 |
Pubmed ID | |
Authors |
Michael J Parsons, Christina Grimm, Jose L Paya-Cano, Cathy Fernandes, Lin Liu, Vivek M Philip, Elissa J Chesler, Wilfried Nietfeld, Hans Lehrach, Leonard C Schalkwyk |
Abstract |
miRNAs are short single-stranded non-coding RNAs involved in post-transcriptional gene regulation that play a major role in normal biological functions and diseases. Little is currently known about how expression of miRNAs is regulated. We surveyed variation in miRNA abundance in the hippocampus of mouse inbred strains, allowing us to take a genetic approach to the study of miRNA regulation, which is novel for miRNAs. The BXD recombinant inbred panel is a very well characterized genetic reference panel which allows quantitative trait locus (QTL) analysis of miRNA abundance and detection of correlates in a large store of brain and behavioural phenotypes. |
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Mendeley readers
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Researcher | 8 | 24% |
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Lecturer | 1 | 3% |
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Unknown | 3 | 9% |
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Psychology | 2 | 6% |
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Unknown | 4 | 12% |