Title |
In depth comparison of an individual’s DNA and its lymphoblastoid cell line using whole genome sequencing
|
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Published in |
BMC Genomics, September 2012
|
DOI | 10.1186/1471-2164-13-477 |
Pubmed ID | |
Authors |
Dorothee Nickles, Lohith Madireddy, Shan Yang, Pouya Khankhanian, Steve Lincoln, Stephen L Hauser, Jorge R Oksenberg, Sergio E Baranzini |
Abstract |
A detailed analysis of whole genomes can be now achieved with next generation sequencing. Epstein Barr Virus (EBV) transformation is a widely used strategy in clinical research to obtain an unlimited source of a subject's DNA. Although the mechanism of transformation and immortalization by EBV is relatively well known at the transcriptional and proteomic level, the genetic consequences of EBV transformation are less well understood. A detailed analysis of the genetic alterations introduced by EBV transformation is highly relevant, as it will inform on the usefulness and limitations of this approach. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 50% |
Germany | 2 | 33% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
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Scientists | 4 | 67% |
Members of the public | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
Germany | 2 | 4% |
Italy | 1 | 2% |
Spain | 1 | 2% |
Unknown | 50 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 32% |
Student > Ph. D. Student | 12 | 21% |
Student > Master | 6 | 11% |
Student > Doctoral Student | 5 | 9% |
Student > Bachelor | 5 | 9% |
Other | 4 | 7% |
Unknown | 6 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 43% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Medicine and Dentistry | 6 | 11% |
Engineering | 2 | 4% |
Business, Management and Accounting | 1 | 2% |
Other | 4 | 7% |
Unknown | 10 | 18% |