@TaurVil @izabelcavassim I was going to point to this paper too and as noted in this thread I don’t know of any methods that take uncertainty in imputation into account explicitly though expect the effect to be small if only common variants are involved.
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@izabelcavassim I saw this paper relatively recently on how it can be affected but not sure about incorporating into the model... https://t.co/qxXtSpAY9Q But maybe @bpasaniuc or @yi_ding_ would have a good place to start looking?
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Polygenic risk scores are great promise, but we need to get them right! @ATorkamani and his group totally get that! @scrippsresearch @ScrippsRTI