Title |
Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children
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Published in |
Virology Journal, September 2012
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DOI | 10.1186/1743-422x-9-205 |
Pubmed ID | |
Authors |
KwiSung Park, BaeckHee Lee, KyoungAh Baek, DooSung Cheon, SangGu Yeo, JoonSoo Park, JaeWan Soh, HaeKyung Cheon, KyungAh Yoon, YoungJin Choi |
Abstract |
Hand-foot-and-mouth disease (HFMD) and herpangina are commonly prevalent illness in young children. They are similarly characterized by lesions on the skin and oral mucosa. Both diseases are associated with various enterovirus serotypes. In this study, enteroviruses from patients with these diseases in Korea in 2009 were isolated and analyzed. Demographic data for patients with HFMD and herpangina were compared and all enterovirus isolates were amplified in the VP1 region by reverse transcription-polymerase chain reaction and sequenced. Among the enterovirus isolates, prevalent agents were coxsackievirus A16 in HFMD and coxsackievirus A5 in herpangina. More prevalent months for HFMD were June (69.2%) and May (11.5%), and June (40.0%) and July (24.0%) for herpangina. Age prevalence of HFMD patients with enterovirus infection was 1 year (23.1%), 4 years (19.2%), and over 5 years (19.2%). However, the dominant age group of herpangina patients with enterovirus infection was 1 year (48.0%) followed by 2 years (28.0%). Comparison of pairwise VP1 nucleotide sequence alignment of all isolates within the same serotypes revealed high intra-type variation of CVA2 isolates (84.6-99.3% nucleotide identity). HFMD and herpangina showed differences in demographic data and serotypes of isolated enteroviruses, but there was no notable difference in amino acid sequences by clinical syndromes in multiple comparison of the partial VP1 gene sequence. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 15% |
Student > Ph. D. Student | 5 | 15% |
Student > Postgraduate | 4 | 12% |
Student > Bachelor | 3 | 9% |
Researcher | 3 | 9% |
Other | 2 | 6% |
Unknown | 11 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 21% |
Agricultural and Biological Sciences | 4 | 12% |
Veterinary Science and Veterinary Medicine | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 5 | 15% |
Unknown | 12 | 36% |