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Sea-Anemone Toxin ATX-II Elicits A-Fiber-Dependent Pain and Enhances Resurgent and Persistent Sodium Currents in Large Sensory Neurons

Overview of attention for article published in Molecular Pain, January 2012
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Title
Sea-Anemone Toxin ATX-II Elicits A-Fiber-Dependent Pain and Enhances Resurgent and Persistent Sodium Currents in Large Sensory Neurons
Published in
Molecular Pain, January 2012
DOI 10.1186/1744-8069-8-69
Pubmed ID
Authors

Alexandra B Klinger, Mirjam Eberhardt, Andrea S Link, Barbara Namer, Lisa K Kutsche, E Theresa Schuy, Ruth Sittl, Tali Hoffmann, Christian Alzheimer, Tobias Huth, Richard W Carr, Angelika Lampert

Abstract

Gain-of-function mutations of the nociceptive voltage-gated sodium channel Nav1.7 lead to inherited pain syndromes, such as paroxysmal extreme pain disorder (PEPD). One characteristic of these mutations is slowed fast-inactivation kinetics, which may give rise to resurgent sodium currents. It is long known that toxins from Anemonia sulcata, such as ATX-II, slow fast inactivation and skin contact for example during diving leads to various symptoms such as pain and itch. Here, we investigated if ATX-II induces resurgent currents in sensory neurons of the dorsal root ganglion (DRGs) and how this may translate into human sensations.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 22%
Student > Ph. D. Student 9 18%
Student > Master 6 12%
Student > Doctoral Student 4 8%
Professor 3 6%
Other 4 8%
Unknown 12 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 27%
Medicine and Dentistry 8 16%
Neuroscience 7 14%
Biochemistry, Genetics and Molecular Biology 4 8%
Unspecified 2 4%
Other 4 8%
Unknown 11 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2014.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from Molecular Pain
#372
of 669 outputs
Outputs of similar age
#172,453
of 250,087 outputs
Outputs of similar age from Molecular Pain
#28
of 47 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,087 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.