Title |
ErbB3 mRNA leukocyte levels as a biomarker for major depressive disorder
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Published in |
BMC Psychiatry, September 2012
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DOI | 10.1186/1471-244x-12-145 |
Pubmed ID | |
Authors |
Elena Milanesi, Alessandra Minelli, Nadia Cattane, Annamaria Cattaneo, Cristina Mora, Alessandro Barbon, Alessandra Mallei, Maurizio Popoli, Vincenzo Florio, Andreas Conca, Stefano Bignotti, Massimo Gennarelli |
Abstract |
In recent years, the identification of peripheral biomarkers that are associated with psychiatric diseases, such as Major Depressive Disorder (MDD), has become relevant because these biomarkers may improve the efficiency of the differential diagnosis process and indicate targets for new antidepressant drugs. Two recent candidate genes, ErbB3 and Fgfr1, are growth factors whose mRNA levels have been found to be altered in the leukocytes of patients that are affected by bipolar disorder in a depressive state. On this basis, the aim of the study was to determine if ErbB3 and Fgfr1 mRNA levels could be a biomarkers of MDD. |
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