Title |
Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
|
---|---|
Published in |
Journal of Hematology & Oncology, September 2012
|
DOI | 10.1186/1756-8722-5-56 |
Pubmed ID | |
Authors |
Bruno Vincenzi, Andrea Napolitano, Alice Zoccoli, Michele Iuliani, Francesco Pantano, Nicola Papapietro, Vincenzo Denaro, Daniele Santini, Giuseppe Tonini |
Abstract |
Recent studies have been reported that angiogenesis suppression may play a role in developing bisphosphonate-related osteonecrosis of the jaw (B-ONJ). According to these evidence we evaluated the role of VEGF as predictive marker of B-ONJ onset. Of the 81 patients, 6 developed B-ONJ following bisphosphonate treatment. These patients showed a strongest decrease in VEGF circulating levels at day 7 and at day 21 after the first administration. These data demonstrated for the first time that the anti-angiogenic properties of bisphosphonates are directly linked to B-ONJ pathogenesis and serum VEGF levels could represent an effective early predictive marker. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 12% |
Student > Ph. D. Student | 4 | 10% |
Other | 3 | 7% |
Student > Doctoral Student | 3 | 7% |
Student > Master | 3 | 7% |
Other | 11 | 27% |
Unknown | 12 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 51% |
Unspecified | 2 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Chemical Engineering | 1 | 2% |
Other | 2 | 5% |
Unknown | 13 | 32% |