Title |
Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma
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Published in |
BMC Cancer, July 2016
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DOI | 10.1186/s12885-016-2451-6 |
Pubmed ID | |
Authors |
Chan Kim, Eun Kyung Kim, Hun Jung, Hong Jae Chon, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Soo Hee Kim, Hyo Song Kim |
Abstract |
The PD-1/PD-L1 axis plays a paramount role in the immune escape of tumor cells by negative regulation of T-cell functions. The aim of the present study was to characterize the PD-L1 expression pattern and its clinical implication in soft-tissue sarcomas (STS). We analyzed PD-L1 expression in 82 STS patients with 5 subtypes: rhabdomyosarcoma, synovial sarcoma, Ewing sarcoma, epithelioid sarcoma, and mesenchymal chondrosarcoma. The median age at diagnosis was 26 (range: 1-78) and the male to female ratio was 1.6. The majority (80 %) of patients showed locoregional disease rather than metastatic disease at diagnosis. Thirty-five cases (43 %) showed PD-L1 expression and the proportion of PD-L1 expression was significantly different according to histologic subtypes (P = 0.004); highest in epithelioid sarcoma (100 %, 7/7), followed by synovial sarcoma (53 %, 10/19), rhabdomyosarcoma (38 %, 12/32), and Ewing sarcoma (33 %, 6/18), while it was not expressed in mesenchymal chondrosarcoma (0 %, 0/6). STS patients with PD-L1 expression had worse overall survival compared with those without PD-L1 expression (5-year survival rate: 48 % vs. 68 %, P = 0.015). The Cox proportional hazard model adjusted for histologic subtype, initial metastasis, and PD-L1 expression showed that PD-L1 expression was significantly associated with shorter overall survival (P = 0.037, HR 2.57, 95 % CI 1.060-6.231). We have confirmed PD-L1 expression in various STS of young population and demonstrated its independent negative prognostic role, thereby suggesting the PD-1/PD-L1 axis as a potential therapeutic target for the treatment of young STS patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
Unknown | 77 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 14 | 18% |
Student > Ph. D. Student | 10 | 13% |
Researcher | 10 | 13% |
Student > Bachelor | 6 | 8% |
Other | 6 | 8% |
Other | 16 | 21% |
Unknown | 16 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 39 | 50% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Agricultural and Biological Sciences | 6 | 8% |
Nursing and Health Professions | 1 | 1% |
Computer Science | 1 | 1% |
Other | 4 | 5% |
Unknown | 20 | 26% |