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Mendeley readers
| Title |
Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression
|
|---|---|
| Published in |
Journal of Neuroinflammation, November 2011
|
| DOI | 10.1186/1742-2094-8-151 |
| Pubmed ID | |
| Authors |
Iciar Gárate, Borja García-Bueno, José LM Madrigal, Lidia Bravo, Esther Berrocoso, Javier R Caso, Juan A Micó, Juan C Leza |
| Abstract |
There is a pressing need to identify novel pathophysiological pathways relevant to depression that can help to reveal targets for the development of new medications. Toll-like receptor 4 (TLR-4) has a regulatory role in the brain's response to stress. Psychological stress may compromise the intestinal barrier, and increased gastrointestinal permeability with translocation of lipopolysaccharide (LPS) from Gram-negative bacteria may play a role in the pathophysiology of major depression. |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 128 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 17% |
| Student > Master | 18 | 14% |
| Researcher | 17 | 13% |
| Student > Bachelor | 13 | 10% |
| Professor > Associate Professor | 12 | 9% |
| Other | 29 | 22% |
| Unknown | 21 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 19% |
| Agricultural and Biological Sciences | 22 | 17% |
| Neuroscience | 13 | 10% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Psychology | 9 | 7% |
| Other | 23 | 17% |
| Unknown | 30 | 23% |