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Mendeley readers
| Title |
Connexin and pannexin channels in cancer
|
|---|---|
| Published in |
BMC Molecular and Cell Biology, May 2016
|
| DOI | 10.1186/s12860-016-0094-8 |
| Pubmed ID | |
| Authors |
Jean X. Jiang, Silvia Penuela |
| Abstract |
Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and their effect in cellular communication, can either enhance or suppress tumorigenesis and metastasis. In this review, we will highlight the latest reports on the role of the well characterized connexin family and its ability to form gap junctions and hemichannels in cancer. We will also introduce the more recently discovered family of pannexin channels and our current knowledge about their involvement in cancer progression. |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 99 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 14% |
| Researcher | 14 | 14% |
| Student > Master | 14 | 14% |
| Student > Bachelor | 10 | 10% |
| Student > Doctoral Student | 9 | 9% |
| Other | 18 | 18% |
| Unknown | 21 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 30% |
| Medicine and Dentistry | 18 | 18% |
| Agricultural and Biological Sciences | 12 | 12% |
| Neuroscience | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Other | 4 | 4% |
| Unknown | 24 | 24% |