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Complete genome sequence of an astrovirus identified in a domestic rabbit (Oryctolagus cuniculus) with gastroenteritis

Overview of attention for article published in Virology Journal, September 2012
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3 X users
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1 Facebook page
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1 Google+ user

Citations

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41 Mendeley
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Title
Complete genome sequence of an astrovirus identified in a domestic rabbit (Oryctolagus cuniculus) with gastroenteritis
Published in
Virology Journal, September 2012
DOI 10.1186/1743-422x-9-216
Pubmed ID
Authors

Mark D Stenglein, Eric Velazquez, Cheryl Greenacre, Rebecca P Wilkes, J Graham Ruby, Julia S Lankton, Donald Ganem, Melissa A Kennedy, Joseph L DeRisi

Abstract

A colony of domestic rabbits in Tennessee, USA, experienced a high-mortality (~90%) outbreak of enterocolitis. The clinical characteristics were one to six days of lethargy, bloating, and diarrhea, followed by death. Heavy intestinal coccidial load was a consistent finding as was mucoid enteropathy with cecal impaction. Preliminary analysis by electron microscopy revealed the presence of virus-like particles in the stool of one of the affected rabbits. Analysis using the Virochip, a viral detection microarray, suggested the presence of an astrovirus, and follow-up PCR and sequence determination revealed a previously uncharacterized member of that family. Metagenomic sequencing enabled the recovery of the complete viral genome, which contains the characteristic attributes of astrovirus genomes. Attempts to propagate the virus in tissue culture have yet to succeed. Although astroviruses cause gastroenteric disease in other mammals, the pathogenicity of this virus and the relationship to this outbreak remains to be determined. This study therefore defines a viral species and a potential rabbit pathogen.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 5%
Unknown 39 95%

Demographic breakdown

Readers by professional status Count As %
Other 8 20%
Student > Bachelor 8 20%
Student > Master 6 15%
Student > Postgraduate 5 12%
Student > Ph. D. Student 5 12%
Other 6 15%
Unknown 3 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 34%
Biochemistry, Genetics and Molecular Biology 9 22%
Veterinary Science and Veterinary Medicine 3 7%
Medicine and Dentistry 3 7%
Immunology and Microbiology 3 7%
Other 4 10%
Unknown 5 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2012.
All research outputs
#12,667,580
of 22,678,224 outputs
Outputs from Virology Journal
#1,155
of 3,030 outputs
Outputs of similar age
#87,954
of 170,921 outputs
Outputs of similar age from Virology Journal
#25
of 104 outputs
Altmetric has tracked 22,678,224 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,030 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.5. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,921 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.