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Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Overview of attention for article published in BMC Structural Biology, January 2012
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About this Attention Score

  • Among the highest-scoring outputs from this source (#34 of 174)
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
1 tweeter
patent
2 patents

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
20 Mendeley
citeulike
1 CiteULike
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Title
Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor
Published in
BMC Structural Biology, January 2012
DOI 10.1186/1472-6807-12-22
Pubmed ID
Authors

Maria A Argiriadi, Eric R Goedken, David Banach, David W Borhani, Andrew Burchat, Richard W Dixon, Doug Marcotte, Gary Overmeyer, Valerie Pivorunas, Ramkrishna Sadhukhan, Silvino Sousa, Nigel St Moore, Medha Tomlinson, Jeffrey Voss, Lu Wang, Neil Wishart, Kevin Woller, Robert V Talanian

Abstract

Structure-based drug design (SBDD) can accelerate inhibitor lead design and optimization, and efficient methods including protein purification, characterization, crystallization, and high-resolution diffraction are all needed for rapid, iterative structure determination. Janus kinases are important targets that are amenable to structure-based drug design. Here we present the first mouse Tyk2 crystal structures, which are complexed to 3-aminoindazole compounds.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 25%
Student > Ph. D. Student 4 20%
Other 3 15%
Professor 2 10%
Student > Master 2 10%
Other 4 20%
Readers by discipline Count As %
Chemistry 5 25%
Agricultural and Biological Sciences 5 25%
Medicine and Dentistry 4 20%
Biochemistry, Genetics and Molecular Biology 3 15%
Computer Science 1 5%
Other 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2016.
All research outputs
#3,469,765
of 12,409,853 outputs
Outputs from BMC Structural Biology
#34
of 174 outputs
Outputs of similar age
#34,227
of 127,462 outputs
Outputs of similar age from BMC Structural Biology
#1
of 5 outputs
Altmetric has tracked 12,409,853 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 174 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,462 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them