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Attention Score in Context
| Title |
Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution
|
|---|---|
| Published in |
Genome Biology, January 2013
|
| DOI | 10.1186/gb-2013-14-1-r10 |
| Pubmed ID | |
| Authors |
Daniël P Melters, Keith R Bradnam, Hugh A Young, Natalie Telis, Michael R May, J Graham Ruby, Robert Sebra, Paul Peluso, John Eid, David Rank, José Fernando Garcia, Joseph L DeRisi, Timothy Smith, Christian Tobias, Jeffrey Ross-Ibarra, Ian Korf, Simon WL Chan |
| Abstract |
BACKGROUND: Centromeres are essential for chromosome segregation, yet their DNA sequences evolve rapidly. In most animals and plants that have been studied, centromeres contain megabase-scale arrays of tandem repeats. Despite their importance, very little is known about the degree to which centromere tandem repeats share common properties between different species across different phyla. We used bioinformatic methods to identify high-copy tandem repeats from 282 species using publicly available genomic sequence and our own data. RESULTS: Our methods are compatible with all current sequencing technologies. Long Pacific Biosciences sequence reads allowed us to find tandem repeat monomers up to 1,419 bp. We assumed that the most abundant tandem repeat is the centromere DNA, which was true for most species whose centromeres have been previously characterized, suggesting this is a general property of genomes. High-copy centromere tandem repeats were found in almost all animal and plant genomes, but repeat monomers were highly variable in sequence composition and length. Furthermore, phylogenetic analysis of sequence homology showed little evidence of sequence conservation beyond approximately 50 million years of divergence. We find that despite an overall lack of sequence conservation, centromere tandem repeats from diverse species showed similar modes of evolution. CONCLUSIONS: While centromere position in most eukaryotes is epigenetically determined, our results indicate that tandem repeats are highly prevalent at centromeres of both animal and plant genomes. This suggests a functional role for such repeats, perhaps in promoting concerted evolution of centromere DNA across chromosomes. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 35% |
| United Kingdom | 3 | 9% |
| Japan | 2 | 6% |
| France | 1 | 3% |
| China | 1 | 3% |
| Cameroon | 1 | 3% |
| Switzerland | 1 | 3% |
| Unknown | 13 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 47% |
| Scientists | 16 | 47% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 417 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 1% |
| Germany | 4 | <1% |
| Czechia | 3 | <1% |
| China | 2 | <1% |
| Brazil | 2 | <1% |
| Norway | 1 | <1% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Mexico | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 393 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 92 | 22% |
| Researcher | 87 | 21% |
| Student > Master | 39 | 9% |
| Student > Bachelor | 36 | 9% |
| Student > Doctoral Student | 25 | 6% |
| Other | 71 | 17% |
| Unknown | 67 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 208 | 50% |
| Biochemistry, Genetics and Molecular Biology | 107 | 26% |
| Computer Science | 9 | 2% |
| Neuroscience | 3 | <1% |
| Medicine and Dentistry | 2 | <1% |
| Other | 12 | 3% |
| Unknown | 76 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2022.
All research outputs
#1,260,517
of 25,374,647 outputs
Outputs from Genome Biology
#956
of 4,467 outputs
Outputs of similar age
#11,068
of 290,717 outputs
Outputs of similar age from Genome Biology
#8
of 48 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,717 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.