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Proteomic analysis of endothelial cold-adaptation

Overview of attention for article published in BMC Genomics, December 2011
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Title
Proteomic analysis of endothelial cold-adaptation
Published in
BMC Genomics, December 2011
DOI 10.1186/1471-2164-12-630
Pubmed ID
Authors

Michael AJ Zieger, Mahesh P Gupta, Mu Wang

Abstract

Understanding how human cells in tissue culture adapt to hypothermia may aid in developing new clinical procedures for improved ischemic and hypothermic protection. Human coronary artery endothelial cells grown to confluence at 37°C and then transferred to 25°C become resistant over time to oxidative stress and injury induced by 0°C storage and rewarming. This protection correlates with an increase in intracellular glutathione at 25°C. To help understand the molecular basis of endothelial cold-adaptation, isolated proteins from cold-adapted (25°C/72 h) and pre-adapted cells were analyzed by quantitative proteomic methods and differentially expressed proteins were categorized using the DAVID Bioinformatics Resource.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
France 1 2%
India 1 2%
China 1 2%
United States 1 2%
Unknown 39 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 23%
Student > Ph. D. Student 9 20%
Student > Master 8 18%
Student > Bachelor 3 7%
Student > Postgraduate 3 7%
Other 8 18%
Unknown 3 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 39%
Biochemistry, Genetics and Molecular Biology 7 16%
Medicine and Dentistry 5 11%
Environmental Science 1 2%
Unspecified 1 2%
Other 7 16%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2012.
All research outputs
#18,316,001
of 22,679,690 outputs
Outputs from BMC Genomics
#8,144
of 10,615 outputs
Outputs of similar age
#195,575
of 243,188 outputs
Outputs of similar age from BMC Genomics
#222
of 296 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,615 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,188 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 296 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.