Title |
Assessment of measurement properties of peak VO2in children with pulmonary arterial hypertension
|
---|---|
Published in |
BMC Pulmonary Medicine, September 2012
|
DOI | 10.1186/1471-2466-12-54 |
Pubmed ID | |
Authors |
Joseph C Cappelleri, Lie-Ju Hwang, Jack Mardekian, Marko A Mychaskiw |
Abstract |
The 6-minute walk test evaluates the effect of pharmacologic intervention in adults with pulmonary arterial hypertension (PAH) but, for reasons of compliance or reliability, may not be appropriate for children at all ages. Thus, peak oxygen consumption (VO2, maximal exercise test) was used instead in a pediatric PAH trial (STARTS-1) to evaluate pharmacologic intervention with sildenafil. This was the first large placebo-controlled trial to use the peak VO2 endpoint in this population. Our working hypothesis was that, as with other populations, percentage changes in peak VO2 in pediatric patients with PAH are reliable and are associated with changes in other clinical endpoints. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Netherlands | 1 | 1% |
Unknown | 90 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 20 | 22% |
Student > Bachelor | 12 | 13% |
Researcher | 12 | 13% |
Student > Ph. D. Student | 8 | 9% |
Other | 6 | 6% |
Other | 8 | 9% |
Unknown | 27 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 31% |
Nursing and Health Professions | 8 | 9% |
Social Sciences | 7 | 8% |
Psychology | 5 | 5% |
Sports and Recreations | 4 | 4% |
Other | 3 | 3% |
Unknown | 37 | 40% |