Title |
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer
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Published in |
Molecular Cancer, September 2012
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DOI | 10.1186/1476-4598-11-73 |
Pubmed ID | |
Authors |
Sandeep Singh, Jose Trevino, Namrata Bora-Singhal, Domenico Coppola, Eric Haura, Soner Altiok, Srikumar P Chellappan |
Abstract |
Cancer stem cells are thought to be responsible for the initiation and progression of cancers. In non-small cell lung cancers (NSCLCs), Hoechst 33342 dye effluxing side population (SP) cells are shown to have stem cell like properties. The oncogenic capacity of cancer stem-like cells is in part due to their ability to self-renew; however the mechanistic correlation between oncogenic pathways and self-renewal of cancer stem-like cells has remained elusive. Here we characterized the SP cells at the molecular level and evaluated its ability to generate tumors at the orthotopic site in the lung microenvironment. Further, we investigated if the self-renewal of SP cells is dependent on EGFR mediated signaling. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 2% |
United Kingdom | 1 | <1% |
China | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 124 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 22% |
Researcher | 22 | 17% |
Student > Master | 17 | 13% |
Student > Bachelor | 9 | 7% |
Student > Doctoral Student | 9 | 7% |
Other | 24 | 18% |
Unknown | 21 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 38 | 29% |
Biochemistry, Genetics and Molecular Biology | 30 | 23% |
Medicine and Dentistry | 22 | 17% |
Chemistry | 6 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 7 | 5% |
Unknown | 24 | 18% |