Title |
Genistein inhibits cell invasion and motility by inducing cell differentiation in murine osteosarcoma cell line LM8
|
---|---|
Published in |
BMC Molecular and Cell Biology, September 2012
|
DOI | 10.1186/1471-2121-13-24 |
Pubmed ID | |
Authors |
Atsushi Nakamura, Junichi Aizawa, Kenshi Sakayama, Teruki Kidani, Tomoyo Takata, Yoshiaki Norimatsu, Hiromasa Miura, Hiroshi Masuno |
Abstract |
One of the problems associated with osteosarcoma is the frequent formation of micrometastases in the lung prior to diagnosis because the development of metastatic lesions often causes a fatal outcome. Therefore, the prevention of pulmonary metastases during the early stage of tumor development is critical for the improvement of the prognosis of osteosarcoma patients. In Japan, soy is consumed in a wide variety of forms, such as miso soup and soy sauce. The purpose of this study is to investigate the effect of genistein, an isoflavone found in soy, on the invasive and motile potential of osteosarcoma cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 3 | 21% |
Student > Ph. D. Student | 2 | 14% |
Researcher | 2 | 14% |
Student > Bachelor | 1 | 7% |
Student > Master | 1 | 7% |
Other | 3 | 21% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |