Title |
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
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Published in |
BMC Cancer, May 2011
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DOI | 10.1186/1471-2407-11-201 |
Pubmed ID | |
Authors |
Benoit Hedan, Rachael Thomas, Alison Motsinger-Reif, Jerome Abadie, Catherine Andre, John Cullen, Matthew Breen |
Abstract |
Histiocytic malignancies in both humans and dogs are rare and poorly understood. While canine histiocytic sarcoma (HS) is uncommon in the general domestic dog population, there is a strikingly high incidence in a subset of breeds, suggesting heritable predisposition. Molecular cytogenetic profiling of canine HS in these breeds would serve to reveal recurrent DNA copy number aberrations (CNAs) that are breed and/or tumor associated, as well as defining those shared with human HS. This process would identify evolutionarily conserved cytogenetic changes to highlight regions of particular importance to HS biology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 17% |
Colombia | 1 | 17% |
United States | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
United States | 1 | 1% |
Unknown | 94 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 20% |
Other | 13 | 14% |
Student > Ph. D. Student | 13 | 14% |
Researcher | 11 | 11% |
Student > Postgraduate | 10 | 10% |
Other | 13 | 14% |
Unknown | 17 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 30 | 31% |
Medicine and Dentistry | 21 | 22% |
Agricultural and Biological Sciences | 15 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 5% |
Environmental Science | 2 | 2% |
Other | 3 | 3% |
Unknown | 20 | 21% |