Title |
S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner
|
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Published in |
BMC Molecular and Cell Biology, April 2005
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DOI | 10.1186/1471-2121-6-21 |
Pubmed ID | |
Authors |
Tarja Kokkola, Juha R Savinainen, Kati S Mönkkönen, Montse Durán Retamal, Jarmo T Laitinen |
Abstract |
Recent studies indicate that the G protein-coupled receptor (GPCR) signaling machinery can serve as a direct target of reactive oxygen species, including nitric oxide (NO) and S-nitrosothiols (RSNOs). To gain a broader view into the way that receptor-dependent G protein activation -- an early step in signal transduction -- might be affected by RSNOs, we have studied several receptors coupling to the Gi family of G proteins in their native cellular environment using the powerful functional approach of [35S]GTPgammaS autoradiography with brain cryostat sections in combination with classical G protein activation assays. |
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