Title |
In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8
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Published in |
BMC Neurology, July 2016
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DOI | 10.1186/s12883-016-0630-3 |
Pubmed ID | |
Authors |
Dimitri Renard, Laurent Collombier, Christel Castelli, Jean-Pierre Pouget, Pierre-Olivier Kotzki, Vincent Boudousq |
Abstract |
In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correlation between CTG-numbers and FDG-PET. FDG-PET was performed in 24 patients and compared to 24 controls. Pearson's correlation was used to analyse correlation. SPM8 revealed Brodmann area 8 as the area with the most severe reduced FDG-uptake. Weak, although not statistically significant, correlation was observed between CTG-numbers and reduced FDG-uptake in Brodmann area 8. In DM1, Brodmann area 8 is the area with the most severe reduced FDG-uptake on FDG-PET. Brodmann area 8 reduced FDG-uptake is correlated -although weakly- to CTG-repeat numbers. |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 36% |
Student > Ph. D. Student | 3 | 21% |
Professor | 1 | 7% |
Other | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 36% |
Medicine and Dentistry | 5 | 36% |
Psychology | 1 | 7% |
Business, Management and Accounting | 1 | 7% |
Unknown | 2 | 14% |