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Mendeley readers
Attention Score in Context
| Title |
Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice
|
|---|---|
| Published in |
Molecular Neurodegeneration, July 2016
|
| DOI | 10.1186/s13024-016-0107-2 |
| Pubmed ID | |
| Authors |
Lan-yan Lin, Jing Zhang, Xiao-man Dai, Nai-an Xiao, Xi-lin Wu, Zhen Wei, Wen-ting Fang, Yuan-gui Zhu, Xiao-chun Chen |
| Abstract |
Apolipoprotein E (ApoE) is a major lipid carrier that supports lipid transport and injury repair in the brain. The APOE ε4 allele is associated with depression, mild cognitive impairment (MCI) and dementia; however, the precise molecular mechanism through which ApoE4 influences the risk of disease development remains unknown. To address this gap in knowledge, we investigated the potential effects of chronic unpredictable mild stress (CUMS) on ApoE3 and ApoE4 target replacement (ApoE3-TR and ApoE4-TR) mice. All ApoE-TR mice exposed to CUMS at 3 months old recovered from a depression-like state by the age of 12 months. Of note, ApoE4-TR mice, unlike age-matched ApoE3-TR mice, displayed impaired spatial cognitive abilities, loss of GABAergic neurons, decreased expression of Reelin, PSD95, SYN and Fyn, and reduced phosphorylation of NMDAR2B and CREB. These results suggest that early-life stress may mediate cognitive impairment in middle-age ApoE4-TR mice through sustained reduction of GABAergic neurons and Reelin expression, which might further diminish the activation of the Fyn/NMDAR2B signaling pathway. |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 102 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 18% |
| Student > Master | 17 | 17% |
| Student > Bachelor | 13 | 13% |
| Student > Doctoral Student | 11 | 11% |
| Researcher | 9 | 9% |
| Other | 12 | 12% |
| Unknown | 22 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 22 | 21% |
| Agricultural and Biological Sciences | 18 | 17% |
| Psychology | 16 | 16% |
| Medicine and Dentistry | 9 | 9% |
| Nursing and Health Professions | 3 | 3% |
| Other | 6 | 6% |
| Unknown | 29 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2018.
All research outputs
#4,760,001
of 25,374,647 outputs
Outputs from Molecular Neurodegeneration
#621
of 977 outputs
Outputs of similar age
#79,029
of 370,093 outputs
Outputs of similar age from Molecular Neurodegeneration
#15
of 19 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,093 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.